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榮獲金球獎(jiǎng)最佳戲劇類(lèi)電視劇集！榮獲艾美獎(jiǎng)最佳戲劇類(lèi)影集選角！螢?zāi)谎輪T公會(huì)最佳戲劇類(lèi)電視劇集！故事延續(xù)第三季精采的劇情。西雅圖恩典醫(yī)院因?yàn)檫@些實(shí)習(xí)醫(yī)生之間的愛(ài)恨情仇，變得更加熱鬧更有可看性！第三季中格蕾終於擺脫了德瑞克和獸醫(yī)間的三角戀情，依自己的心意選擇了所愛(ài)的人。伊茲在丹尼死后一厥不振，甚至想要放棄成為外科醫(yī)生的夢(mèng)想。克莉絲汀知道了柏克的秘密后，一直企圖幫他掩飾。而喬治和性感火辣的住院醫(yī)師之間的關(guān)係變得更迷離。而艾立克斯竟發(fā)現(xiàn)自己還是愛(ài)著伊茲！另外，馬克為了艾蒂森竟也來(lái)到了西雅圖恩典醫(yī)院工作。Meredith和Cristina蜜月歸來(lái)（買(mǎi)好的機(jī)票不好浪費(fèi)~），Burke已經(jīng)消失無(wú)蹤。去年的實(shí)習(xí)醫(yī)生Meredith, Cristina, Izzie和Alex，已經(jīng)獲得了正式駐院醫(yī)生的資格，并且有了自己的跟班，一群初出茅廬，青澀而稚嫩的實(shí)習(xí)醫(yī)生。當(dāng)中，有去年考試不及格的George，還有Meredith素未謀面的妹妹Lexie Grey。今天，他們將要處理一宗三車(chē)連環(huán)相撞的交通意外，大量的傷者讓新來(lái)的實(shí)習(xí)手足無(wú)措，目瞪口呆。另一邊廂，Derek和Meredith的感情陷入僵局，有可能他們都會(huì)和新來(lái)的同事有新的感情發(fā)展。Bailey對(duì)于Callie成為駐院總醫(yī)生感到氣憤，也許她一時(shí)三刻還難以接受自己現(xiàn)在要向Callie匯報(bào)工作。Richard留任外科主任，仍然是大家的老大~(簡(jiǎn)介轉(zhuǎn)自YDY)After failing his exam, George reluctantly faces his first day reliving his internship among a sea of fresh faces. Meanwhile, Cristina, Meredith, Izzie and Alex are in charge of their own interns and George is assigned to Meredith.Neither Cristina or Meredith have heard from her exes since the wedding, and they don't seem overly concerned, which astounds Izzie, who is counting every day since she last spoke to George. George asks to talk to Meredith but before he can get her alone, the rest of the new interns show up in the hall and are shooed off by the residents. George gives up and joins the interns. Cristina nicknames him "Bambi," saying he needs to learn how to deal with his new situation.